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MYP_071597
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Basic Information
Casein beta [193-209], Casecidin 17
Anticancer
Anticancer ▸ Apoptosis induction
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Hemostasis ▸ Antithrombotic activity
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Sensory / Food function ▸ Taste-active peptide
Sensory / Food function ▸ Taste-active peptide ▸ Bitter peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
17 amino acids
C91H141N21O22
Standard
Sequence
YQEPVLGPVRGPFPIIV
Physicochemical Analysis
1881.22 Da
6.00
-0.24
-0.44
-0.0140
0.48
0.37
0.34
67.40
120.00
0.1176
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
656.28
-1.87
20.0
22.0
52.0
134.0
6.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0246569 VERIFIED: YES
Provenance & Taxonomy
Bubalus bubalis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0256538 VERIFIED: NO
Provenance & Taxonomy
Bos taurus [Animal]
Casein-derived peptide
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Taste
RECORD: Rec_0275314 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Isracidin
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
MIC
PaperAntimicrobial activity of two peptides casecidin 15 and 17, found naturally in bovine colostrum | Birkemo, GA. et al. | DOI: 10.1111/j.1365-2672.2008.03996.x Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
RECORD: Rec_0280437 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
proteolytic peptide fragment [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Salmonella spp.
Microtitre antimicrobial assay
PaperAntibacterial Activities of Peptides from the Water-Soluble Extracts of Italian cheese Varieties
RECORD: Rec_0282929 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casein-derived peptide
9913
Structure & Mods
linear contiguous peptide sequence [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Bitter
PaperProduction and sensory characterization of a bitter peptide from beta-casein. J. Agric. Food Chem., 53, 1185-1189 PMID15713038 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15713038/
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