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MYP_071597
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Basic Information
Casein beta [193-209], Casecidin 17
Anticancer
Anticancer ▸ Apoptosis induction
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Hemostasis ▸ Antithrombotic activity
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Sensory / Food function ▸ Taste-active peptide
Sensory / Food function ▸ Taste-active peptide ▸ Bitter peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
17 amino acids
C91H141N21O22
Standard
Sequence
YQEPVLGPVRGPFPIIV
Physicochemical Analysis
1881.22 Da
6.00
-0.24
-0.44
-0.0140
0.48
0.37
0.34
67.40
120.00
0.1176
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
656.28
-1.87
20.0
22.0
52.0
134.0
6.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0006328 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casein-derived peptide
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Immunomodulator Anti-Gram-negative
Escherichia coli
400 μg/mL
MIC
RECORD: Rec_0029734 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
beta-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
ACE inhibitory Antihypertensive
Angiotensin-converting enzyme (ACE)
101 μM
IC50
PaperAntihypertensive Effect of the Peptides Derived from Casein by an Extracellular Proteinase from Lactobacillus helveticus CP790 | Yamamoto, N. et al. | DOI: 10.3168/jds.S0022-0302(94)77026-0 Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
RECORD: Rec_0034772 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
PaperIdentification of angiotensin-I-converting enzyme inhibitory peptides derived from sodium caseinate hydrolysates produced by Lactobacillus helveticus NCC 2765 PMID15537298 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15537298/
RECORD: Rec_0056261 VERIFIED: YES
Provenance & Taxonomy
Bubalus bubalis [Animal]
89462
Structure & Mods
proteolytic peptide fragment [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory Antioxidant Immunomodulatory Antimicrobial Antibacterial
Angiotensin-converting enzyme (ACE)
ACE inhibition assay
PaperCharacterization of the microbial diversity and chemical composition of Gouda cheese made by potential probiotic strains as an adjunct starter culture; Improved functionality of fermented milk is mediated by the synbiotic interaction between Cudrania tricuspidata leaf extract and Lactobacillus gasseri strains; Antibacterial Activities of Peptides from the Water-Soluble Extracts of Italian cheese Varieties; Antithrombotic and angiotensin-converting enzyme inhibitory properties of peptides released from bovine Casein by Lactobacillus casei Shirota; Comparative analysis of b-Casein proteolysis by PrtP proteinase from Lactobacillus paracasei subsp. paracasei BGHN14, PrtR proteinase from Lactobacillus rhamnosus BGT10 and PrtH proteinase from Lactobacillus helveticus BGRA43; Peptidomic analysis reveals proteolytic activity of kefir microorganisms on bovine milk proteins; PMID 1169462; Casein hydrolysis by Bifidobacterium longum KACC91563 and antioxidant activities of peptides derived therefrom; Identification of angiotensin-I-converting enzyme inhibitory peptides derived from sodium caseinate hydrolysates produced by Lactobacillus helveticus NCC 2765; Variability of hydrolysis of β-, αs1-, and αs2-caseins by 10 strains of Streptococcus thermophilus and resulting bioactive peptides; A peptide derived from bovine beta-casein modulates functional properties of bone marrow-derived macrophages from germfree and human flora-associated mice; Angiotensin-converting enzyme inhibitory activity in Mexican Fresco cheese; Identification of antihypertensive peptides derived from low molecular weight casein hydrolysates generated during fermentation by Bifidobacterium longum KACC 91563; Angiotensin converting enzyme-inhibitory activity in Cheddar cheeses made with the addition of probiotic Lactobacillus casei sp. PMID27606488;26996626;26616950;1169462;23871374;15537298;22103626;11694622;21787916;26877633 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27606488/
RECORD: Rec_0061452 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
proteolytic peptide fragment [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli K12
Microtitre antimicrobial assay
PaperAntibacterial Activities of Peptides from the Water-Soluble Extracts of Italian cheese Varieties
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