Peptide Database

Peptide NameLantibiotic

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length48 amino acids

Chemical FormulaC225H359N57O77S5

DescriptionStandard

        MKNSKDILTNAIEEVSEKELMEVAGDKKGSGWFATITDDCPNSVFVCC
    

Molecular Weight5254.92 Da

Isoelectric Point (pI)4.40

Net Charge (pH 7.0)-4.52

Net Charge (pH 7.4) -4.79

Charge Density (pH 7.0) -0.0941

GRAVY Index-0.21

Hydrophobic Moment 0.54

Boman Index0.03

Instability Index33.68

Aliphatic Index 71.04

Aromaticity 0.0625

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5625.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2174.70

LogP -23.39

H-bond Donors 76.0

H-bond Acceptors 78.0

Rotatable Bonds 179.0

Heavy Atoms 364.0

Ring Count 5.0

Amide Bonds 50.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0415646 VERIFIED: NO

Provenance & Taxonomy

OrganismStreptococcus pyogenes [Bacterium]

FamilyLantibiotic

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive Non-hemolytic Non-ribosomal

TargetGram-positive bacteria

MethodQualitative functional evidence