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MYP_071318
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Basic Information
Ocellatin-F1, OF1 (Fallaxin) [Cleaved into: Fallaxin(1-22) (Ocellatin-LB1) ]
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Antiviral
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
25 amino acids
C113H198N32O32S
Standard
Sequence
GVVDILKGAAKDIAGHLASKVMNKL
Physicochemical Analysis
2549.04 Da
9.53
1.85
1.58
0.0738
0.43
0.59
0.18
3.78
128.80
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1032.40
-8.74
35.0
36.0
90.0
178.0
1.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0083106 VERIFIED: YES
Provenance & Taxonomy
Leptodactylus fallax [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
40 μM
MIC
PMID15544856 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15544856/
RECORD: Rec_0086808 VERIFIED: YES
Provenance & Taxonomy
Leptodactylus labyrinthicus [Animal]
Frog skin active peptide (FSAP); Ocellatin subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Defense peptide Antimicrobial Antibiotic Antiviral Antifungal Anti-Candida Hemolytic
No Target Organism Found
PMID26635873;28115922;29596881 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26635873/
RECORD: Rec_0098667 VERIFIED: NO
Provenance & Taxonomy
Leptodactylus fallax,Leptodactylus dominicensis [Animal]; Leptodactylus labyrinthicus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Gram negative
RECORD: Rec_0102318 VERIFIED: YES
Provenance & Taxonomy
Leptodactylus fallax [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Klebsiella pneumoniae
80 μM
MIC
PMID15544856 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15544856/
RECORD: Rec_0104993 VERIFIED: YES
Provenance & Taxonomy
Leptodactylus fallax [Animal]
Fallaxin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Hemolytic Cytolytic
Erythrocytes
200.0 μM
HC50
PaperL.A. Rollins-Smith et al. / Regulatory Peptides 124 (2005) 173-178. An antimicrobial peptide from the skin secretions of the mountain chicken frog Leptodactylus fallax (Anura:Leptodactylidae)
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