Peptide Database

Peptide NameSetmelanotide

Function Ontology

Melanocortin agonist Weight management

Standard StatusStandard

Sequence Length8 amino acids

Chemical FormulaC47H67N17O9S2

DescriptionStandard

        RCAHFRWC
    

Molecular Weight1078.27 Da

Isoelectric Point (pI)9.02

Net Charge (pH 7.0)1.83

Net Charge (pH 7.4) 1.54

Charge Density (pH 7.0) 0.2284

GRAVY Index-0.44

Hydrophobic Moment 0.17

Boman Index-0.28

Instability Index56.77

Aliphatic Index 12.50

Aromaticity 0.2500

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5625.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 435.29

LogP -2.87

H-bond Donors 19.0

H-bond Acceptors 14.0

Rotatable Bonds 31.0

Heavy Atoms 75.0

Ring Count 4.0

Amide Bonds 7.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0072591 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; synthetic construct [Synthetic]

FamilyMelanocortin

Tax ID9606;32630

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitymixed L/D amino-acid peptide [Mixed]

N-TermAcetylation

C-TermAmidation

Disulfide2月8日

Bio-Activity Profile

Function

Melanocortin agonist Weight management

TargetMelanocortin receptor MC4R

Half-LifeClinical/Human: Elimination half-life of approximately 11 h