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MYP_071211
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Basic Information
Las[C8-C25, Ala17,27]
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
27 amino acids
C129H238N38O28S2
Standard
Sequence
GLPRKILCAIAKKKGKAKGPLKLVCKA
Physicochemical Analysis
2833.64 Da
10.49
8.73
8.49
0.3234
0.02
0.62
-0.06
2.24
112.22
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1072.40
-6.92
39.0
39.0
102.0
197.0
2.0
26.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0112633 VERIFIED: YES
Provenance & Taxonomy
Lasioglossum laticeps [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Hemolytic activity
200 μM
LC50
PMID22038181 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22038181/
RECORD: Rec_0114158 VERIFIED: YES
Provenance & Taxonomy
Lasioglossum laticeps [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
100 μM
MIC
PMID22038181 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22038181/
RECORD: Rec_0215387 VERIFIED: YES
Provenance & Taxonomy
Lasioglossum laticeps [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Bacillus subtilis
0.5 μM
MIC
PMID22038181 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22038181/
RECORD: Rec_0268995 VERIFIED: YES
Provenance & Taxonomy
Lasioglossum laticeps [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
65 μM
MIC
PMID22038181 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22038181/
RECORD: Rec_0287489 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
200 μM
Hemolysis
PaperMonincová L, Slaninová J, Fučík V, et al. Lasiocepsin, a novel cyclic antimicrobial peptide from the venom of eusocial bee Lasioglossum laticeps (Hymenoptera: Halictidae). Amino Acids. 2012 Aug;43(2):751-761. doi:10.1007/s00726-011-1125-6. PMID22038181 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22038181/
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