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MYP_071142
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Basic Information
Rugosin-LK1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
33 amino acids
C152H274N42O46S3
Standard
Sequence
SIRDKIKTMAIDLAKSAGTGVLKTLICKLDKSC
Physicochemical Analysis
3522.25 Da
9.51
3.44
3.19
0.1042
0.18
0.55
-0.00
2.73
112.42
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1445.82
-14.55
54.0
53.0
127.0
243.0
0.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0027058 VERIFIED: YES
Provenance & Taxonomy
Limnonectes kuhlii [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial Antifungal
Staphylococcus aureus ATCC 2592
10 μg/mL
MIC
PaperFive novel antimicrobial peptides from the Kuhl's wart frog skin secretions, Limnonectes kuhlii.
RECORD: Rec_0078955 VERIFIED: YES
Provenance & Taxonomy
Limnonectes kuhlii [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0080687 VERIFIED: YES
Provenance & Taxonomy
Limnonectes kuhlii [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans ATCC 2002
10 μg/mL
MIC
PaperFive novel antimicrobial peptides from the Kuhl's wart frog skin secretions, Limnonectes kuhlii.
RECORD: Rec_0086719 VERIFIED: YES
Provenance & Taxonomy
Limnonectes kuhlii [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial Antifungal
Pseudomonas aeruginosa ATCC 27853
5 μg/mL
MIC
PaperFive novel antimicrobial peptides from the Kuhl's wart frog skin secretions, Limnonectes kuhlii.
RECORD: Rec_0111817 VERIFIED: YES
Provenance & Taxonomy
Limnonectes kuhlii [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa PA01
5 μg/mL
MIC
PMID23054029 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23054029/
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