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MYP_071117
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Basic Information
Interferon-induced double-stranded RNA-activated protein kinase
Antiviral
Antiviral ▸ Anti-Alphavirus ▸ Anti-Semliki Forest virus
Antiviral ▸ Anti-Arenavirus ▸ Anti-Mammarenavirus ▸ Anti-LCMV
Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV
Antiviral ▸ Anti-Rotavirus
Regulatory peptide ▸ Biological modulation
Standard
515 amino acids
C2571H4062N718O792S18
Standard
Sequence
MASDTPGFYMDKLNKYRQMHGVAITYKELSTSGPPHDRRFTFQVLIDEKEFPEAKGRSKQEARNAAAKLAVDILDNENKVDCHTSASEQGLFVGNYIGLVNSFAQKKKLSVNYEQCEPNSELPQRFICKCKIGQTMYGTGSGVTKQEAKQLAAKEAYQKLLKSPPKTAGTSSSVVTSTFSGFSSSSSMTSNGVSQSAPGSFSSENVFTNGLGENKRKSGVKVSPDDVQRNKYTLDARFNSDFEDIEEIGLGGFGQVFKAKHRIDGKRYAIKRVKYNTEKAEHEVQALAELNHVNIVQYHSCWEGVDYDPEHSMSDTSRYKTRCLFIQMEFCDKGTLEQWMRNRNQSKVDKALILDLYEQIVTGVEYIHSKGLIHRDLKPGNIFLVDERHIKIGDFGLATALENDGKSRTRRTGTLQYMSPEQLFLKHYGKEVDIFALGLILAELLHTCFTESEKIKFFESLRKGDFSNDIFDNKEKSLLKKLLSEKPKDRPETSEILKTLAEWRNISEKKKRNTC
Physicochemical Analysis
58279.26 Da
8.76
8.62
7.43
0.0167
-0.66
0.58
-0.12
45.21
70.82
0.0893
41830.00
42330.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0035927 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
PKR
10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Anti-RSV Interferon pathway modulator Translation regulator
Respiratory syncytial virus (RSV)
PaperProtein kinase R is a novel mediator of CD40 signaling and plays a critical role in modulating immunoglobulin expression during respiratory syncytial virus infection PMID21994357 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21994357/
RECORD: Rec_0194260 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
PKR
10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Anti-Rotavirus Translation regulator
Rotavirus
PaperProtein kinase R is responsible for the phosphorylation of eIF2alpha in rotavirus infection PMID20631127 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20631127/
RECORD: Rec_0355606 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
PKR
10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Anti-Semliki-Forest-virus Translation regulator Interferon pathway modulator
Semliki Forest virus
PaperPKR acts early in infection to suppress Semliki Forest virus production and strongly enhances the type I interferon response PMID19264662 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19264662/
RECORD: Rec_0400827 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
PKR
10090
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Anti-LCMV Translation regulator Interferon pathway modulator
Lymphocytic choriomeningitis virus (LCMV)
PaperRole of PKR and Type I IFNs in viral control during primary and secondary infection PMID20585572 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20585572/