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MYP_070990
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Basic Information
Catestatin
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Cardiovascular
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune cell migration ▸ Chemotactic peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Standard
21 amino acids
C104H164N32O27S
Standard
Sequence
SSMKLSFRARAYGFRGPGPQL
Physicochemical Analysis
2326.68 Da
11.72
3.46
3.25
0.1647
-0.49
0.31
-0.10
15.74
46.67
0.1429
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
963.47
-10.52
35.0
32.0
74.0
164.0
5.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0221028 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antioxidant
T. rubrum
75 μM
MIC
PaperNew antimicrobial activity for the catecholamine release-inhibitory peptide from chromogranin A
RECORD: Rec_0253265 VERIFIED: YES
Provenance & Taxonomy
Pan paniscus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0260985 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antioxidant
Escherichia coli O29
30 μM
MIC
PaperNew antimicrobial activity for the catecholamine release-inhibitory peptide from chromogranin A
RECORD: Rec_0264827 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Candida glabrata
240 μg/mL
MIC
PMID35216181 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35216181/
RECORD: Rec_0276903 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
chromogranin/secretogranin protein family
9606; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
2-Ser: Phosphoserine; 3-Met: Methionine sulfoxide
Bio-Activity Profile
Other chromogranin secretogranin protein family Antifungal Host defense
PaperPDB 1LV4 structural record; NMR; chain A; residues 1-21
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