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MYP_070978
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Basic Information
IN1(designed based on indolicidin and ranalexin)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
13 amino acids
C101H136N26O14
Standard
Sequence
LLPWKWPWWKWRR
Physicochemical Analysis
1938.33 Da
12.00
3.76
3.55
0.2891
-1.30
0.42
-0.13
63.68
60.00
0.3846
27500.00
27500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
649.73
3.73
25.0
18.0
53.0
141.0
12.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0320550 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
human RBCs
PaperAntimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae. PLoS One. 2015 Jun 5;10(6):e0128532. doi: 10.1371/journal.pone.0128532. PMID: 26046345. PMID26046345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26046345/
RECORD: Rec_0350445 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
S.pneumoniae
31.25 - 62.5 μg/mL
MIC
PMID26046345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26046345/
RECORD: Rec_0358963 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Streptococcus pneumoniae(30 clinical isolates)
31.25-62.5 μg/mL
MIC
PaperAntimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae. PLoS One. 2015 Jun 5;10(6):e0128532. doi: 10.1371/journal.pone.0128532. PMID: 26046345. PMID26046345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26046345/
RECORD: Rec_0372117 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Methicillin resistant Staphylococcus aureus (MRSA)
31.25 μg/mL
MIC
PaperAntimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae. PLoS One. 2015 Jun 5;10(6):e0128532. doi: 10.1371/journal.pone.0128532. PMID: 26046345. PMID26046345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26046345/
RECORD: Rec_0384621 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Enterococcus cloacae
250 μg/mL
MIC
PaperAntimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae. PLoS One. 2015 Jun 5;10(6):e0128532. doi: 10.1371/journal.pone.0128532. PMID: 26046345. PMID26046345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26046345/
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