‹ ›
MYP_070961
← PREVIOUS NEXT → BACK
Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
17 amino acids
C99H154N34O20S4
Standard
Sequence
RWCFRVCYRGICYRKCR
Physicochemical Analysis
2268.76 Da
9.93
5.72
5.45
0.3363
-0.52
0.72
-0.44
13.22
40.00
0.2353
8480.00
8730.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
920.69
-6.48
41.0
30.0
72.0
157.0
5.0
16.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0110116 VERIFIED: YES
Provenance & Taxonomy
Tachypleus tridentatus [Animal]
Tachyplesin
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans M9
3.1 μg/mL
MIC
PaperAntimicrobial peptides, isolated from horseshoe crab hemocytes, tachyplesin II, and polyphemusins I and II: chemical structures and biological activity.
RECORD: Rec_0111574 VERIFIED: YES
Provenance & Taxonomy
Limulus polyphemus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0120353 VERIFIED: YES
Provenance & Taxonomy
Tachypleus tridentatus [Animal]
Tachyplesin
6853
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PaperJ Biochem. 1989 Oct;106(4):663-8. | http://www.ncbi.nlm.nih.gov/pubmed/2514185 PMID2514185 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2514185/
RECORD: Rec_0153879 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hemolytic
human red blood cells
55.4±6.6 μM
HC50
PMID31455019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31455019/
RECORD: Rec_0176628 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli DC2 CGSC 7139
0.125-0.5 μM
MIC
PMID31455019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31455019/
FIRST PREV 1 2 3 4 ... 6 NEXT LAST
Showing 5 records on this page · Page 2 of 6