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MYP_070911
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Basic Information
M-oxotoxin-Ot1a (Oxyopinin-1, Oxki1; spiders, Arthropods, animals)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Insecticidal/Pest control ▸ Insecticidal activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
48 amino acids
C235H409N71O60S
Standard
Sequence
FRGLAKLLKIGLKSFARVLKKVLPKAAKAGKALAKSMADENAIRQQNQ
Physicochemical Analysis
5221.27 Da
11.26
9.76
9.54
0.2032
-0.20
0.90
-0.10
6.91
103.96
0.0417
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2172.62
-19.45
75.0
71.0
189.0
367.0
3.0
52.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0308894 VERIFIED: YES
Provenance & Taxonomy
Oxyopes takobius [Animal]
Cationic peptide 02 (oxyopinin-2)
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Anti-Gram-positive Cytolytic Toxin Hemolytic Insecticidal
Staphylococcus aureus
PMID11976325;15328050 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11976325/
RECORD: Rec_0342398 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Insecticidal
Sheep erythrocytes
50 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/11976325/ PMID11976325 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11976325/
RECORD: Rec_0347899 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Guinea-pig erythrocytes
2.5 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/15328050/ PMID15328050 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15328050/
RECORD: Rec_0357685 VERIFIED: YES
Provenance & Taxonomy
Oxyopes kitabensis [Animal]
Oxyopinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PaperJ Biol Chem. 2002 Jun 28;277(26):23627-37. Epub 2002 Apr 25. | http://www.ncbi.nlm.nih.gov/pubmed/11976325 PMID11976325 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11976325/
RECORD: Rec_0363026 VERIFIED: YES
Provenance & Taxonomy
Oxyopes kitabensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Insecticidal
Staphylococcus aureus
6.2 μM
MIC
PaperOxyopinins, large amphipathic peptides isolated from the venom of the wolf spider Oxyopes kitabensis with cytolytic properties and positive insecticidal cooperativity with spider neurotoxins
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