Peptide Database

Peptide NameDENV Envelope glycoprotein (340 - 354)

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC64H108N24O20

DescriptionStandard

        GQGKAHNGRLITANP
    

Molecular Weight1533.69 Da

Isoelectric Point (pI)11.00

Net Charge (pH 7.0)1.85

Net Charge (pH 7.4) 1.59

Charge Density (pH 7.0) 0.1231

GRAVY Index-0.91

Hydrophobic Moment 0.27

Boman Index-0.11

Instability Index1.86

Aliphatic Index 65.33

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 728.03

LogP -10.53

H-bond Donors 24.0

H-bond Acceptors 23.0

Rotatable Bonds 50.0

Heavy Atoms 108.0

Ring Count 2.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0275585 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-DENV Entry inhibition

TargetDENV-2 | Vero cells

Activity10 μM

MethodIC50

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperIn vitro analysis of synthetic peptides in blocking the entry of dengue virus. | John AM, Jittmittraphap A, Chattanadee S, Alwin Prem Anand A, Shenbagarathai R, Leaungwutiwong P. | Virus Res. 2019 Jan 15;260:142-150. | DOI:10.1016/j.virusres.2018.11.016 | PMID:30508603 PMID30508603 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30508603/

RECORD: Rec_0353062 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetDENV-4

RECORD: Rec_0362455 VERIFIED: NO

Provenance & Taxonomy

OrganismDengue virus [Virus]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral

TargetActive against DENV-1

RECORD: Rec_0380632 VERIFIED: NO

Provenance & Taxonomy

OrganismDengue virus [Virus]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral

TargetDENV-6

RECORD: Rec_0382639 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-DENV Entry inhibition

TargetDENV-1 | Vero cells

Activity33 μM

MethodIC50

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperIn vitro analysis of synthetic peptides in blocking the entry of dengue virus. | John AM, Jittmittraphap A, Chattanadee S, Alwin Prem Anand A, Shenbagarathai R, Leaungwutiwong P. | Virus Res. 2019 Jan 15;260:142-150. | DOI:10.1016/j.virusres.2018.11.016 | PMID:30508603 PMID30508603 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30508603/

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