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MYP_070843
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Basic Information
DENV Envelope glycoprotein (340 - 354)
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
15 amino acids
C64H108N24O20
Standard
Sequence
GQGKAHNGRLITANP
Physicochemical Analysis
1533.69 Da
11.00
1.85
1.59
0.1231
-0.91
0.27
-0.11
1.86
65.33
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
728.03
-10.53
24.0
23.0
50.0
108.0
2.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0102131 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-DENV Entry inhibition
DENV-3 | Vero cells
20 μM
% inhibition
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperIn vitro analysis of synthetic peptides in blocking the entry of dengue virus. | John AM, Jittmittraphap A, Chattanadee S, Alwin Prem Anand A, Shenbagarathai R, Leaungwutiwong P. | Virus Res. 2019 Jan 15;260:142-150. | DOI:10.1016/j.virusres.2018.11.016 | PMID:30508603 PMID30508603 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30508603/
RECORD: Rec_0130566 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
DENV-2:inhibition of virus infection in Vero cells
10 μM
IC50
PMID30508603 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30508603/
RECORD: Rec_0148412 VERIFIED: YES
Provenance & Taxonomy
Dengue virus [Virus]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
DENV-3
PMID30508603 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30508603/
RECORD: Rec_0166278 VERIFIED: YES
Provenance & Taxonomy
Dengue virus [Virus]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
DENV-2
PMID30508603 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30508603/
RECORD: Rec_0242062 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
DENV-1:inhibition of virus infection in Vero cells(83%±3.72% inhibition at 50 μM
33 μM
IC50
PMID30508603 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30508603/
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