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MYP_070712
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Basic Information
Cyclotide mela-7
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
29 amino acids
C131H206N34O40S6
Standard
Sequence
GLPTCGETCFKGKCYTPGCSCSYPICKKN
Physicochemical Analysis
3089.63 Da
8.64
2.70
2.40
0.0930
-0.32
0.39
0.00
15.23
26.90
0.1034
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1177.83
-14.79
46.0
49.0
96.0
211.0
6.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0297048 VERIFIED: NO
Provenance & Taxonomy
Melicytus latifolius [Plant]
Cyclotide
Structure & Mods
backbone-cyclized cyclotide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperCyclotide mela-7 Evidence URLhttps://www.uniprot.org/uniprotkb/C0HK34/entry
RECORD: Rec_0328678 VERIFIED: YES
Provenance & Taxonomy
Melicytus latifolius [Animal]
Cyclotide
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperPubMed PMID: 26322745 PMID26322745 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26322745/
RECORD: Rec_0350602 VERIFIED: YES
Provenance & Taxonomy
Melicytus latifolius [Animal]
Cyclotide
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Human erythrocytes: >64μM
50 %
Hemolysis
PaperPubMed PMID: 26322745 PMID26322745 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26322745/
RECORD: Rec_0371769 VERIFIED: YES
Provenance & Taxonomy
Melicytus latifolius [Animal]
Cyclotide
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
MM96L
1.58±0.48 μM
CC50
PaperPubMed PMID: 26322745 PMID26322745 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26322745/
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