Peptide Database

Peptide NameSLAY-screened peptide P5357

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC106H161N31O30S3

DescriptionStandard

        CPSFNSSARHYFMLVRSMTPN
    

Molecular Weight2445.80 Da

Isoelectric Point (pI)9.50

Net Charge (pH 7.0)1.84

Net Charge (pH 7.4) 1.57

Charge Density (pH 7.0) 0.0874

GRAVY Index-0.28

Hydrophobic Moment 0.57

Boman Index-0.03

Instability Index86.69

Aliphatic Index 37.14

Aromaticity 0.1429

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 987.78

LogP -11.71

H-bond Donors 36.0

H-bond Acceptors 36.0

Rotatable Bonds 74.0

Heavy Atoms 170.0

Ring Count 6.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0143640 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Familyp53-derived

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/