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MYP_070422
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Basic Information
Crotalicidin
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
34 amino acids
C203H345N53O37S
Standard
Sequence
KRFKKFFKKVKKSVKKRLKKIFKKPMVIGVTIPF
Physicochemical Analysis
4152.31 Da
12.00
14.75
14.52
0.4337
-0.44
0.82
-0.23
4.32
80.00
0.1471
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1508.56
-4.61
54.0
53.0
152.0
294.0
7.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0340901 VERIFIED: YES
Provenance & Taxonomy
Crotalus durissus terrificus [Animal]
Cathelicidin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Enterococcus faecalis
32 μg/mL
MIC
PMID25100358 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25100358/
RECORD: Rec_0355449 VERIFIED: YES
Provenance & Taxonomy
Rattlesnake Venom Cathelicidin [Animal]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
U-937 (IC50 < 1 μM )
PaperPubMed PMID: 26465972 PMID26465972 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26465972/
RECORD: Rec_0378693 VERIFIED: YES
Provenance & Taxonomy
Crotalus durissus terrificus [Animal]
cathelicidin family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial cathelicidin family Antibacterial Host defense
PaperPDB 2MWT structural record; NMR; chain A; residues 1-34
RECORD: Rec_0390205 VERIFIED: YES
Provenance & Taxonomy
American pit [Animal]; Animalia [Animal]
33208; 33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID25100358 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25100358/
RECORD: Rec_0398035 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on American pit vipers [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Acinetobacter baumannii clinical isolate
3.8 μM
MIC
Serum 71 min
PaperVipericidins: a novel family of cathelicidin-related peptides from the venom gland of South American pit vipers.
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