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MYP_070422
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Basic Information
Crotalicidin
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
34 amino acids
C203H345N53O37S
Standard
Sequence
KRFKKFFKKVKKSVKKRLKKIFKKPMVIGVTIPF
Physicochemical Analysis
4152.31 Da
12.00
14.75
14.52
0.4337
-0.44
0.82
-0.23
4.32
80.00
0.1471
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1508.56
-4.61
54.0
53.0
152.0
294.0
7.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0306257 VERIFIED: YES
Provenance & Taxonomy
Crotalus durissus [Animal]
Cathelicidin
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
32 μg/mL
MIC
PMID25100358 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25100358/
RECORD: Rec_0311090 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on American pit vipers [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Pseudomonas aeruginosa ATCC 27853 and a clinical isolate
0.24-3.8 μM
MIC
Serum 71 min
PaperVipericidins: a novel family of cathelicidin-related peptides from the venom gland of South American pit vipers.
RECORD: Rec_0318351 VERIFIED: YES
Provenance & Taxonomy
Crotalus durissus terrificus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
THP-1 leukemia cells
1.56 μM
IC50
PaperCrotalicidin/cathelicidin-related peptide literature; DRAMP/Crotalicidin records PMID26465972;25100358
RECORD: Rec_0332911 VERIFIED: YES
Provenance & Taxonomy
Crotalus durissus terrificus [Animal]
Cathelicidin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
1 μg/mL
MIC
PMID25100358 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25100358/
RECORD: Rec_0340901 VERIFIED: YES
Provenance & Taxonomy
Crotalus durissus terrificus [Animal]
Cathelicidin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Enterococcus faecalis
32 μg/mL
MIC
PMID25100358 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25100358/
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