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MYP_070422
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Basic Information
Crotalicidin
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
34 amino acids
C203H345N53O37S
Standard
Sequence
KRFKKFFKKVKKSVKKRLKKIFKKPMVIGVTIPF
Physicochemical Analysis
4152.31 Da
12.00
14.75
14.52
0.4337
-0.44
0.82
-0.23
4.32
80.00
0.1471
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1508.56
-4.61
54.0
53.0
152.0
294.0
7.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0006032 VERIFIED: YES
Provenance & Taxonomy
Crotalus durissus terrificus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
7.5 μM
MIC
RECORD: Rec_0019621 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on American pit vipers [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
C. krusei ATCC 6258
40 μM
MIC
Serum 71 min
PaperVipericidins: a novel family of cathelicidin-related peptides from the venom gland of South American pit vipers.
RECORD: Rec_0023235 VERIFIED: YES
Provenance & Taxonomy
Rattlesnake Venom Cathelicidin [Animal]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
THP-1
1.56 μM
IC50
PaperPubMed PMID: 26465972 PMID26465972 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26465972/
RECORD: Rec_0039881 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on American pit vipers [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
cancer cells HeLa S3 and U937, in the low uM range for THP-1
~1.56 μM
IC50
Serum 71 min
PaperVipericidins: a novel family of cathelicidin-related peptides from the venom gland of South American pit vipers.
RECORD: Rec_0053087 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on American pit vipers [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Dermatophythes M. canis LABMIC 0401
1.25 μM
MIC
Serum 71 min
PaperVipericidins: a novel family of cathelicidin-related peptides from the venom gland of South American pit vipers.
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