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MYP_070418
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Basic Information
Stigmurin
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Wound healing/Regeneration ▸ Wound healing
Standard
17 amino acids
C89H138N18O21
Standard
Sequence
FFSLIPSLVGGLISAFK
Physicochemical Analysis
1796.16 Da
8.75
0.76
0.55
0.0447
1.54
0.40
0.60
12.47
137.65
0.1765
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
606.84
-2.34
21.0
22.0
56.0
128.0
4.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0317955 VERIFIED: YES
Provenance & Taxonomy
Scorpion Tityus stigmurus [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Staphylococcus epidermidis (ATCC 12228)
9.4 μM
MIC
PMID30709056 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30709056/
RECORD: Rec_0324250 VERIFIED: YES
Provenance & Taxonomy
Tityus stigmurus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal Antiparasitic Anticancer Hemolytic
PMID29670004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29670004/
RECORD: Rec_0357505 VERIFIED: YES
Provenance & Taxonomy
Tityus stigmurus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal Antiparasitic Anticancer Cytotoxic
HeLa cell lines
Cell viability assay
PMID29670004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29670004/
RECORD: Rec_0361283 VERIFIED: YES
Provenance & Taxonomy
Scorpion Tityus stigmurus [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida krusei (ATCC 6258)
150 μM
MIC
PMID30709056 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30709056/
RECORD: Rec_0365446 VERIFIED: YES
Provenance & Taxonomy
Tityus stigmurus [Animal]
Stigmurin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal Cytotoxic Anti-mammalian cells
PaperPeptides. 2015 Jun;68:3-10 | http://www.ncbi.nlm.nih.gov/pubmed/25805002 PMID25805002 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25805002/
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