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MYP_070418
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Basic Information
Stigmurin
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Wound healing/Regeneration ▸ Wound healing
Standard
17 amino acids
C89H138N18O21
Standard
Sequence
FFSLIPSLVGGLISAFK
Physicochemical Analysis
1796.16 Da
8.75
0.76
0.55
0.0447
1.54
0.40
0.60
12.47
137.65
0.1765
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
606.84
-2.34
21.0
22.0
56.0
128.0
4.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0029279 VERIFIED: YES
Provenance & Taxonomy
Tityus stigmurus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Antioxidant Wound healing
E.cloacae ATCC 13047
>150 μM
MIC
PaperStructural characterization of a novel peptide with antimicrobial activity from the venom gland of the scorpion Tityus stigmurus: Stigmurin
RECORD: Rec_0045868 VERIFIED: YES
Provenance & Taxonomy
Scorpion Tityus stigmurus [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
PMID30709056 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30709056/
RECORD: Rec_0067092 VERIFIED: YES
Provenance & Taxonomy
Tityus stigmurus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal Antiparasitic Anticancer
Stigmurin inhibit 90% of the epimastigote forms of Trypanosoma cruzi growth at 25 ?M
PMID29670004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29670004/
RECORD: Rec_0071585 VERIFIED: YES
Provenance & Taxonomy
Scorpion Tityus stigmurus [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli (ATCC 25922)
150 μM
MIC
PMID30709056 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30709056/
RECORD: Rec_0078038 VERIFIED: YES
Provenance & Taxonomy
Scorpion Tityus stigmurus [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Pseudomonas aeruginosa (ATCC 27853)
150 μM
MIC
PMID30709056 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30709056/
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