Peptide Database

Peptide NameCorticotropin

Function Ontology

Antimicrobial

Cardiovascular

Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier

Delivery / Targeting ▸ Drug delivery vehicle

Hormonal / Endocrine ▸ Hormone peptide

Immunology ▸ Inflammation modulation ▸ Anti-inflammatory

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide precursor

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Regulatory peptide ▸ Cell-cell communication

Standard StatusStandard

Sequence Length39 amino acids

Chemical FormulaC207H308N56O58S

DescriptionStandard

        SYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEF
    

Molecular Weight4541.07 Da

Isoelectric Point (pI)8.09

Net Charge (pH 7.0)0.56

Net Charge (pH 7.4) 0.28

Charge Density (pH 7.0) 0.0143

GRAVY Index-0.98

Hydrophobic Moment 0.62

Boman Index-0.16

Instability Index53.68

Aliphatic Index 40.00

Aromaticity 0.1538

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1836.25

LogP -15.16

H-bond Donors 63.0

H-bond Acceptors 61.0

Rotatable Bonds 145.0

Heavy Atoms 322.0

Ring Count 12.0

Amide Bonds 39.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0162046 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0170907 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial

TargetB-uniformis ATCC 8492

Activity>50 μM

MethodMIC

RECORD: Rec_0178481 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hormone

RECORD: Rec_0183269 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial

TargetB-vulgatus ATCC 8482

Activity>50 μM

MethodMIC

RECORD: Rec_0195280 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyACTH

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Endocrine stimulant Anti-inflammatory

TargetHuman melanocortin receptors / adrenal cortex

Half-LifeClinical/Human: 15 min (IV)

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