Peptide Database

Peptide NameNeocarzinostatin (NCS) (Mitomalcin) (MMC)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length147 amino acids

Chemical FormulaC629H1001N175O205S5

DescriptionStandard

        MVPISIIRNRVAKVAVGSAAVLGLAVGFQTPAVAAAPTATVTPSSGLSDGTVVKVAGAGLQAGTAYDVGQCAWVDTGVLACNPADFSSVTADANGSASTSLTVRRSFEGFLFDGTRWGTVDCTTAACQVGLSDAAGNGPEGVAISFN
    

Molecular Weight14455.05 Da

Isoelectric Point (pI)4.53

Net Charge (pH 7.0)-3.53

Net Charge (pH 7.4) -3.81

Charge Density (pH 7.0) -0.0240

GRAVY Index0.44

Hydrophobic Moment 0.49

Boman Index0.24

Instability Index26.11

Aliphatic Index 86.33

Aromaticity 0.0612

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12740.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5979.55

LogP -79.81

H-bond Donors 212.0

H-bond Acceptors 207.0

Rotatable Bonds 454.0

Heavy Atoms 1014.0

Ring Count 17.0

Amide Bonds 155.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0086382 VERIFIED: YES

Provenance & Taxonomy

OrganismStreptomyces carzinostaticus [Bacterium]

FamilyNeocarzinostatin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-positive Cytotoxic Non-hemolytic

TargetGram-positive bacteria

RECORD: Rec_0300373 VERIFIED: NO