Peptide Database

Peptide NameE1P42

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC112H152N26O31

DescriptionStandard

        ESEFWRWTEQLASNYWIL
    

Molecular Weight2358.56 Da

Isoelectric Point (pI)4.25

Net Charge (pH 7.0)-2.16

Net Charge (pH 7.4) -2.33

Charge Density (pH 7.0) -0.1199

GRAVY Index-0.64

Hydrophobic Moment 0.60

Boman Index0.07

Instability Index80.66

Aliphatic Index 70.56

Aromaticity 0.2778

Extinction Coeff. Reduced 17990.00

Extinction Coeff. Oxidized 17990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 946.29

LogP -4.47

H-bond Donors 34.0

H-bond Acceptors 29.0

Rotatable Bonds 72.0

Heavy Atoms 169.0

Ring Count 8.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0033943 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyAurein

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral

TargetHIV-1 NL4-3

Activity50.0±8.7 μM

MethodIC50

RECORD: Rec_0139156 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetVirus:HIV-1 NL4-3:inhibition of virus infection in TZM-bl cells

Activity50±8.7 μM

MethodIC50

RECORD: Rec_0378831 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

TargetHIV-1 NL4-3 | TZM-bl cells

Activity50±8.7 μM

MethodIC50

Half-LifeMammalian: 1 h; Yeast: 30 min; E. coli: >10 h

PaperDefinition of an 18-mer Synthetic Peptide Derived from the GB virus C E1 Protein as a New HIV-1 Entry Inhibitor. | Gómara MJ, Sánchez-Merino V, Paús A, Merino-Mansilla A, Gatell JM, Yuste E, Haro I. | Biochim Biophys Acta. 2016 Jun;1860(6):1139-48. | DOI:10.1016/j.bbagen.2016.02.008 | PMID:26905802 PMID26905802 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26905802/