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MYP_070353
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Basic Information
Ranatuerin-2SEa
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Adverse immune reactivity ▸ Histamine-release modulation
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Immunology ▸ Innate immune modulation ▸ Mast cell modulation
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
29 amino acids
C126H216N34O40S2
Standard
Sequence
GFISTVKNLATNVAGTVIDTIKCKVTGGC
Physicochemical Analysis
2911.40 Da
8.86
1.74
1.50
0.0599
0.60
0.51
0.24
-12.09
100.69
0.0345
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1201.04
-15.04
44.0
44.0
97.0
202.0
1.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0160418 VERIFIED: YES
Provenance & Taxonomy
Rana sevosa [Animal]
Ranatuerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Micrococcus luteus NCT C2665
PMID16386333 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16386333/
RECORD: Rec_0161455 VERIFIED: YES
Provenance & Taxonomy
Lithobates sevosus [Animal]
Ranatuerin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
23-29
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
110.0 μM
MIC
PaperM.F. Ali et al. / Biochimica et Biophysica Acta 1601 (2002) 55-63. Antimicrobial peptides and protease inhibitors in the skin secretions of the crawfish frog, Rana areolata Evidence URLhttps://www.uniprot.org/uniprotkb/P85057/entry
RECORD: Rec_0166273 VERIFIED: YES
Provenance & Taxonomy
Lithobates sevosus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0168623 VERIFIED: YES
Provenance & Taxonomy
Rana areolata [Animal]
Ranatuerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
23-29
Bio-Activity Profile
Antimicrobial
Weakly active againt Escherichia coli
110 μM
MIC
PaperAntimicrobial peptides and protease inhibitors in the skin secretions of the crawfish frog, Rana areolata.
RECORD: Rec_0185033 VERIFIED: YES
Provenance & Taxonomy
Lithobates sevosus [Animal]
Frog skin active peptide (FSAP); Ranatuerin subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Defense peptide Antimicrobial Antibiotic Anti-Gram-negative Non-hemolytic
Escherichia coli (Gram-negative)
PMID16386333 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16386333/
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