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MYP_070348
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Basic Information
Meucin-24
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxin
Venom / Toxin ▸ Toxin
Standard
24 amino acids
C116H201N37O36S2
Standard
Sequence
GRGREFMSNLKEKLSGVKEKMKNS
Physicochemical Analysis
2754.19 Da
10.17
3.76
3.55
0.1568
-1.30
0.50
-0.41
29.66
44.58
0.0417
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1245.29
-14.57
44.0
42.0
104.0
191.0
1.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0005391 VERIFIED: YES
Provenance & Taxonomy
Mesobuthus eupeus [Animal]
Meucin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0040752 VERIFIED: YES
Provenance & Taxonomy
Mesobuthus eupeus [Animal]
long chain scorpion toxin family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Toxin Venom long chain scorpion toxin family
PaperPDB 2KFE structural record; NMR; chain A; residues 1-24
RECORD: Rec_0058684 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Meucin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium berghei ANKA 2.34
10-20 μM
Percent inhibition; Microscopy (Giemsa staining)
PMID20097251 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20097251/
RECORD: Rec_0091710 VERIFIED: YES
Provenance & Taxonomy
Mesobuthus eupeus [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimalarial
mouse erythrocytes even at 100 μM
PaperPubMed PMID: 20097251 PMID20097251 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20097251/
RECORD: Rec_0094635 VERIFIED: YES
Provenance & Taxonomy
Mesobuthus eupeus [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimalarial Hemolytic
PaperPubMed PMID: 20097251 PMID20097251 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20097251/
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