Peptide Database

Peptide NameToxin KTx8

Function Ontology

Membrane / Ion-channel modulation ▸ Ion channel modulation

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length40 amino acids

Chemical FormulaC180H301N53O51S7

DescriptionStandard

        VPTGGCPLSDSLCAKYCKSHKFGKTGRCTGPNKMKCKCLV
    

Molecular Weight4248.10 Da

Isoelectric Point (pI)9.42

Net Charge (pH 7.0)6.75

Net Charge (pH 7.4) 6.39

Charge Density (pH 7.0) 0.1689

GRAVY Index-0.33

Hydrophobic Moment 0.50

Boman Index-0.08

Instability Index51.74

Aliphatic Index 46.25

Aromaticity 0.0500

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1666.57

LogP -20.42

H-bond Donors 64.0

H-bond Acceptors 66.0

Rotatable Bonds 141.0

Heavy Atoms 291.0

Ring Count 6.0

Amide Bonds 40.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0128467 VERIFIED: YES

Provenance & Taxonomy

OrganismLychas mucronatus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Toxin Ion Channel Blocker Potassium Channel Blocker

TargetKv1

Activity0.0264 ± 0.00162 μM

MethodIC50