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MYP_070328
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Basic Information
HR1-30a
Antiviral
Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Standard
56 amino acids
C268H458N70O83
Standard
Sequence
AVSKVLHLEGEVNKISALLSTNKAVVSLSNGVSVLTSKVLDLDNYIDKQLLPIVNK
Physicochemical Analysis
5988.92 Da
8.35
0.89
0.63
0.0158
0.34
0.53
0.14
15.87
142.50
0.0179
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2487.17
-24.41
84.0
85.0
207.0
421.0
3.0
61.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0238745 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Contains non-standard symbols/residues: -.
Bio-Activity Profile
Antiviral Anti-RSV Fusion inhibition
Respiratory syncytial virus(RSV) | of cell; Hep2 cells
1.68 μM
IC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperBoth heptad repeats of human respiratory syncytial virus fusion protein are potent inhibitors of viral fusion. | Wang E, Sun X, Qian Y, Zhao L, Tien P, Gao GF. | Biochem Biophys Res Commun. 2003 Mar 14;302(3):469-75. | DOI:10.1016/s0006-291x(03)00197-9 | PMID:12615056 PMID12615056 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12615056/
RECORD: Rec_0348982 VERIFIED: YES
Provenance & Taxonomy
Human orthopneumovirus [Virus]
Heptad repeat peptide
11250;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Fusion inhibitor
Respiratory syncytial virus (Fusion); Hep2
1.68 μM
Cell-fusion assay
PaperBoth heptad repeats of human respiratory syncytial virus fusion protein are potent inhibitors of viral fusion. | Wang E, Sun X, Qian Y, Zhao L, Tien P, Gao GF. | Biochem Biophys Res Commun. 2003 | PMID:12615056 PMID12615056 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12615056/