Peptide Database

Peptide NameAlpha-defensin 1

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length98 amino acids

Chemical FormulaC458H757N143O147S7

DescriptionStandard

        MRTLTLLTALLLLALQVQTQSLEETADQVPAQDQPGAEAQDITISFAGDERSAREASKSLIGTASCTCRRAWICRWGERHSGKCIDQKGSTYRLCCRR
    

Molecular Weight10843.24 Da

Isoelectric Point (pI)8.29

Net Charge (pH 7.0)1.55

Net Charge (pH 7.4) 1.17

Charge Density (pH 7.0) 0.0158

GRAVY Index-0.36

Hydrophobic Moment 0.75

Boman Index-0.12

Instability Index50.54

Aliphatic Index 80.82

Aromaticity 0.0408

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4744.92

LogP -57.50

H-bond Donors 176.0

H-bond Acceptors 157.0

Rotatable Bonds 367.0

Heavy Atoms 755.0

Ring Count 9.0

Amide Bonds 105.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0127886 VERIFIED: YES

Provenance & Taxonomy

OrganismEquus caballus [Animal]

FamilyAlpha-defensin; Defensin

Tax ID9796

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Defensin Anti-Gram-negative Anti-Gram-positive Hemolytic

TargetP. multocida (Gram-negative)

RECORD: Rec_0134480 VERIFIED: YES

Provenance & Taxonomy

OrganismEquus caballus [Animal]

FamilyAlpha-defensin; Defensin

Tax ID9796

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Defensin Anti-Gram-negative Anti-Gram-positive Hemolytic

TargetR. equi

RECORD: Rec_0280330 VERIFIED: YES

Provenance & Taxonomy

OrganismEquus caballus [Animal]

FamilyAlpha-defensin; Defensin

Tax ID9796

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Defensin Anti-Gram-negative Anti-Gram-positive Hemolytic

TargetS. dysgalactiae (Gram-positive)

RECORD: Rec_0300012 VERIFIED: YES

Provenance & Taxonomy

OrganismEquus caballus [Animal]

FamilyAlpha-defensin; Defensin

Tax ID9796

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Defensin Anti-Gram-negative Anti-Gram-positive Hemolytic

TargetS. equi (Gram-positive)

RECORD: Rec_0367158 VERIFIED: YES

Provenance & Taxonomy

OrganismEquus caballus [Animal]

FamilyAlpha-defensin; Defensin

Tax ID9796

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Defensin Anti-Gram-negative Anti-Gram-positive Hemolytic

TargetS. choleraesuis