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MYP_070232
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Basic Information
Oncocin [D2Orn,P12W,P13Hyp,R15Hyp,I16Tle,R19Orn]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
19 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
VXKPPYLPRPRWXRXXYNX
Physicochemical Analysis
0.00 Da
0.00
0.00
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0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0215356 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Oncocin
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D or modified amino-acid peptide [Mixed]
None
Amidation
x=trans-4-hydroxyproline; X(16)=tert-Leu; X(2/19)=Orn
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PMID26334348 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26334348/
RECORD: Rec_0246595 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
Ornithine, x: trans-4-hydroxyproline at 2,13,15,19; non-canonical residue code at 16; Ornithine, x: trans-4-hydroxyproline
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli
PMID26334348 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26334348/
RECORD: Rec_0272338 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Oncocin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: HeLa (15% loss of viability=600μg/mL)
PMID26334348 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26334348/
RECORD: Rec_0290573 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Amidation
Ornithine, x: trans-4-hydroxyproline at 2,13,15,19; non-canonical residue code at 16; Ornithine, x: trans-4-hydroxyproline
Bio-Activity Profile
Antimicrobial Antibacterial
Klebsiella pneumoniae
PMID26334348 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26334348/
RECORD: Rec_0350901 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Oncocin
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D or modified amino-acid peptide [Mixed]
None
Amidation
x=trans-4-hydroxyproline; X(16)=tert-Leu; X(2/19)=Orn
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
μg/ml
600 μg/mL
Cytotoxicity
PMID26334348 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26334348/
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