Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length379 amino acids

Chemical FormulaC1920H3115N501O543S15

DescriptionStandard

        MKSSLLHFFFLVSFISSDTAAPPPGIKVRITEKVKDLGLMYLKGLVNQQFQIEKKDLPIKSVTLTKLQVDPTQVDLKFQQNIGLQFEIKDLNFALELQREKNVHFFKEFKIDKGTTIFTGEGVRAMILVRMNQNPKGHLNVEIRKEDCKITADTIKTKSTGFIGKVLDLFKRLTKHFFKKKICPALQPMINNKLKDLSMIKTVHEGRQLDLDYSLSSDIAVTSRSLDMSFKGLMFVHGKDVDTNSIKPGIEPVFTETNHMVYVGISEFFFNGAAMAIYKSGPFEVNVPKLEGLRSIVNVLLGAVGIQPGLLKVKLTEAPIIQISKAGLSATVDIETQSEGQQSVHVSCKLDMNVKFEASRLIPVVKTPKCNVETQKIIG
    

Molecular Weight42386.28 Da

Isoelectric Point (pI)9.39

Net Charge (pH 7.0)13.19

Net Charge (pH 7.4) 12.40

Charge Density (pH 7.0) 0.0348

GRAVY Index-0.06

Hydrophobic Moment 0.82

Boman Index0.06

Instability Index23.35

Aliphatic Index 99.45

Aromaticity 0.0739

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 6210.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0078033 VERIFIED: NO

Provenance & Taxonomy

OrganismHaplochromis burtoni [Bacterium]

FamilyBPI

Tax ID8153

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence