Peptide Database

Peptide NameM-myrmeciitoxin-Mp1 (M-MIITX-Mp1) (Allergen Myr p I) (Major allergen Myr p 1) (Pilosulin-1) (allergen Myr p 1) [Cleaved into: M-myrmeciitoxin-Mp1a (M-MIITX-Mp1a) (M-myrmeciitoxin-Mp1b) (M-MIITX-Mp1b) (Pilosulin-1 57->112) (Myr p 1 57->112) (Myr p 1 57->112 (Ile5)) ([Ile-5]pilosulin-1); M-myrmeciitoxin-Mp1c (M-MIITX-Mp1c) (Pilosulin-1 65->112) (Myr p 1 65->112); M-myrmeciitoxin-Mp1d (M-MIITX-Mp1d) (Pilosulin-1 68->112) (Myr p 1 68->112); M-myrmeciitoxin-Mp1e (M-MIITX-Mp1e) (Pilosulin-1 71->112) (Myr p 1 71->112); U1-myrmeciitoxin-Mp1f (U1-MIITX-Mp1f) (Pilosulin-1 86->112) (Myr p 1 86->112)]

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length112 amino acids

Chemical FormulaC532H881N139O154S5

DescriptionStandard

        MKLSCLLLTLTIIFVLTIVHAPNVEAKDLADPESEAVGFADAFGEADAVGEADPNAGLGSVFGRLARILGRVIPKVAKKLGPKVAKVLPKVMKEAIPMAVEMAKSQEEQQPQ
    

Molecular Weight11848.85 Da

Isoelectric Point (pI)5.81

Net Charge (pH 7.0)-1.40

Net Charge (pH 7.4) -1.72

Charge Density (pH 7.0) -0.0125

GRAVY Index0.23

Hydrophobic Moment 0.92

Boman Index0.15

Instability Index27.73

Aliphatic Index 108.04

Aromaticity 0.0357

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4620.03

LogP -37.63

H-bond Donors 153.0

H-bond Acceptors 159.0

Rotatable Bonds 398.0

Heavy Atoms 830.0

Ring Count 13.0

Amide Bonds 117.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0027477 VERIFIED: YES

Provenance & Taxonomy

OrganismMyrmecia pilosula [Animal]

FamilyFormicidae venom precursor-01; Ant pilosulin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Cytotoxic Hemolytic

TargetGram Negative Bacteria and Gram Positive Bacteria