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MYP_070178
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Basic Information
Ticin A4
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
42 amino acids
C179H298N50O60S3
Standard
Sequence
SLGVTLGAAGVYTATQTIATQIWKCGAVLTTSAECSRTGKSC
Physicochemical Analysis
4206.78 Da
8.63
1.43
1.17
0.0341
0.37
0.48
0.19
15.06
81.43
0.0476
6990.00
7115.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1772.62
-24.86
68.0
65.0
136.0
292.0
3.0
43.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0011443 VERIFIED: YES
Provenance & Taxonomy
Bacillus thuringiensis [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
APD analysis reveals that the sequence of this peptide most resembles (97.6% similarity) Ticin A3. Active against the tested Gram-positive bacteria, including B. amyloliquefaciens, B. cereus, B. firmus, B. thuringiensis, B. subtilis, B. pumilus, E. faecalis, L. monocytogenes, Microbacterium, Paenibacillus, S. aureus, and S. sciuri. However, they are more active against food-borne pathogens such as B. cereus and L. monocytogenes. Chemical modifications such as dehydration are to be determined
Bio-Activity Profile
Antimicrobial
including B. amyloliquefaciens, Bacillus cereus, B. firmus, B. thuringiensis, Bacillus subtilis, B. pumilus, Enterococcus faecalis, Listeria monocytogenes, Microbacterium, Paenibacillus, Staphylococcus aureus
PaperThree novel lantibiotics ticin A1, A3, and A4 have extremely stable properties and are promising food bio-preservatives.
RECORD: Rec_0043407 VERIFIED: YES
Provenance & Taxonomy
Bacillus thuringiensis BMB3201 [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Bacillus subtilis 168
7.81 μM
MIC
PMID26231642 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26231642/
RECORD: Rec_0048417 VERIFIED: YES
Provenance & Taxonomy
Bacillus thuringiensis BMB3201 [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Bacillus cereus VD 048
0.49 μM
MIC
PMID26231642 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26231642/
RECORD: Rec_0053115 VERIFIED: YES
Provenance & Taxonomy
Bacillus thuringiensis BMB3201 [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Bacillus amyloliquefaciens X1
0.98 μM
MIC
PMID26231642 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26231642/
RECORD: Rec_0071200 VERIFIED: YES
Provenance & Taxonomy
Bacillus thuringiensis [Bacterium]; Bacteria [Bacterium]
1428; 2
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID26231642 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26231642/
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