Peptide Database

Peptide NameRegdanvimab

Function Ontology

Antiviral

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Therapeutic / Biomedical activity ▸ Enzyme replacement therapy

Standard StatusStandard

Sequence Length216 amino acids

Chemical FormulaC995H1552N264O329S5

DescriptionStandard

        ELVLTQPPSVSAAPGQKVTISCSGSSSNIGNNYVSWYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGTSATLGITGLQTGDEADYYCGTWDSSLSAGVFGGGTELTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS
    

Molecular Weight22636.86 Da

Isoelectric Point (pI)6.16

Net Charge (pH 7.0)-1.03

Net Charge (pH 7.4) -1.42

Charge Density (pH 7.0) -0.0048

GRAVY Index-0.35

Hydrophobic Moment 0.51

Boman Index0.06

Instability Index55.73

Aliphatic Index 67.73

Aromaticity 0.0787

Extinction Coeff. Reduced 35410.00

Extinction Coeff. Oxidized 35660.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0057656 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyMonoclonal antibody

Tax ID9606

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Immunomodulatory Enzyme replacement

Half-LifeThe mean terminal half-life of regdanvimab following intravenous administration of 40 mg/kg to patients with COVID-19 was 17 days.[L39140]

RECORD: Rec_0108704 VERIFIED: NO