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MYP_070149
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Basic Information
Unnamed
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hemostasis ▸ Anticoagulant activity
Hemostasis ▸ Antithrombotic activity
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Therapeutic / Biomedical activity ▸ Regenerative medicine ▸ Bone metabolism ▸ Osteoanabolic activity
Standard
10 amino acids
C53H84N14O15
Standard
Sequence
YQEPVLGPVR
Physicochemical Analysis
1157.32 Da
6.00
-0.24
-0.44
-0.0238
-0.42
0.40
0.01
86.04
97.00
0.1000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
470.16
-2.89
15.0
15.0
33.0
82.0
3.0
10.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0226972 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
beta-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
ACE inhibitory Antihypertensive
Angiotensin-converting enzyme (ACE)
300 μM
IC50
PaperAngiotensin-I-converting enzyme-inhibitory peptides in commercial Wisconsin Cheddar cheeses of different ages | Lu, Y. et al. | DOI: 10.3168/jds.2015-9569 Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
RECORD: Rec_0265538 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
beta-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Immunomodulatory Anti-inflammatory Macrophage-modulating
Murine splenocytes
Cell proliferation assay
PaperBuffalo Milk Casein-derived Decapeptide (YQEPVLGPVR) Having Bifunctional Anti-inflammatory and Antioxidative Features Under Cellular Milieu | Kandukuri, S. et al. | DOI: 10.1007/s10989-018-9708-7 Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
RECORD: Rec_0291853 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Osteoanabolic
Epidermal growth factor receptor
PaperPreparation, identification and screening of anti-osteoporosis milk-derived peptides: intervention effects in osteoporosis rats. Food Bioscience 62:105120 (2024). DOI: 10.1016/j.fbio.2024.105120.
RECORD: Rec_0321081 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Enzyme inhibitory ACE inhibitory
ACE
RECORD: Rec_0348219 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casomorphin
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Immunomodulatory Lymphocyte-proliferative
Human peripheral blood lymphocytes
Cell proliferation assay
PaperStimulation of human peripheral blood lymphocytes by bioactive peptides derived from bovine milk proteins | Kayser, H. et al. | DOI: 10.1016/0014-5793(96)00207-4 Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
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