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MYP_070074
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Basic Information
II22N17
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Standard
38 amino acids
C207H362N56O55
Standard
Sequence
KIEEIESKIKKIENEIARIKKLLQLTVWGIKQLQARIL
Physicochemical Analysis
4515.43 Da
9.87
3.77
3.55
0.0991
-0.21
0.83
-0.08
76.06
146.32
0.0263
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1861.07
-10.22
64.0
59.0
168.0
318.0
2.0
41.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0035499 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 | 293T cells; HOS-CD4/fusion cells
0.16±0.01 μM
IC50
Mammalian: 1.3 h; Yeast: 3 min; E. coli: 2 min
PaperDesign of potent inhibitors of HIV-1 entry from the gp41 N-peptide region. | Eckert DM, Kim PS. | Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11187-92. | DOI:10.1073/pnas.201392898 | PMID:11572974 PMID11572974 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11572974/
RECORD: Rec_0064632 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:inhibition of cell-cell fusion between 293T cells and HOS-CD4/fusion cells
0.16±0.01 μM
IC50
PaperPubMed PMID: 11572974 PMID11572974 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11572974/
RECORD: Rec_0198296 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1
PMID11572974 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11572974/
RECORD: Rec_0323641 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 11572974 PMID11572974 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11572974/