Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length354 amino acids

Chemical FormulaC1767H2732N454O506S18

DescriptionStandard

        MLYIVLWSLALVSCICGENPAIQLALTDKGLQTVRHFAAGVIQDKLDQMELTDVRGHVMGIHYTLSGMHITKLDFPEPEVHFSPPVSGLDLSVSGLSMALTGDWSTHLGAIHDGGTFDMAIFDLSLRSFLGLDRDSSGHPSVSSVYCEVDIQTVNMQFYGGARYTHVLSVEVNPVMSLDLSLSAPPAVDPGSINFGLRGEFYSPESHRDPPFVAPPFSLPVQSTYMLSVGVSEYTANSASFAYYISGHLQALINDSMIPSYCPIRLNTSSMGRFIPQLSQMYPDLLMVLQVYARQTPLFTFQPGFVKLDLLSAIKAFVVQANSTLTPVFKLHLVRRTSRSGLVWFSMQRFNILK
    

Molecular Weight39008.50 Da

Isoelectric Point (pI)5.91

Net Charge (pH 7.0)-6.47

Net Charge (pH 7.4) -7.41

Charge Density (pH 7.0) -0.0183

GRAVY Index0.21

Hydrophobic Moment 0.71

Boman Index0.18

Instability Index48.09

Aliphatic Index 96.33

Aromaticity 0.1017

Extinction Coeff. Reduced 35870.00

Extinction Coeff. Oxidized 36120.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0336127 VERIFIED: NO

Provenance & Taxonomy

OrganismPeriophthalmus magnuspinnatus [Bacterium]

FamilyBPI

Tax ID409849

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence