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MYP_070055
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Basic Information
Unnamed
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiviral ▸ Anti-HIV
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
28 amino acids
C128H195N31O36S6
Standard
Sequence
GIACGESCVFLGCFIPGCSCKSKVCYFN
Physicochemical Analysis
2936.49 Da
7.77
0.70
0.40
0.0250
0.88
0.21
0.33
43.02
66.07
0.1429
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1053.58
-10.78
42.0
43.0
92.0
201.0
5.0
28.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0201100 VERIFIED: YES
Provenance & Taxonomy
Psychotria leptothyrsa [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Anticancer Cytotoxic
MCF-7
7.77 μM
IC50
PaperPubMed PMID 20564026 | PubMed PMID 20575510 PMID20564026;20575510 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20564026/
RECORD: Rec_0206872 VERIFIED: NO
Provenance & Taxonomy
Psychotria leptothyrsa [Plant]; Insecta [Animal]
33090; 50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0213800 VERIFIED: YES
Provenance & Taxonomy
Psychotria leptothyrsa [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Anticancer Cytotoxic
Human histiocytic lymphoma U-937/GTB
26 μM
IC50
PaperPubMed PMID 20564026 | PubMed PMID 20575510 PMID20564026;20575510 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20564026/
RECORD: Rec_0220056 VERIFIED: YES
Provenance & Taxonomy
Psychotria leptothyrsa [Animal]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Anti-HIV Anticancer
PaperPubMed PMID: 20575512 PMID20575512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20575512/
RECORD: Rec_0269984 VERIFIED: YES
Provenance & Taxonomy
Psychotria leptothyrsa [Plant]
Psychotria leptothyrsa
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial
PMID20575512;18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20575512/
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