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MYP_070055
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Basic Information
Unnamed
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiviral ▸ Anti-HIV
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
28 amino acids
C128H195N31O36S6
Standard
Sequence
GIACGESCVFLGCFIPGCSCKSKVCYFN
Physicochemical Analysis
2936.49 Da
7.77
0.70
0.40
0.0250
0.88
0.21
0.33
43.02
66.07
0.1429
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1053.58
-10.78
42.0
43.0
92.0
201.0
5.0
28.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0079079 VERIFIED: YES
Provenance & Taxonomy
Psychotria leptothyrsa [Animal]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Anti-HIV Anticancer Cytotoxic
the human lymphoma cell line U-937 GTB
26 μM
IC50
PaperPubMed PMID: 20575512 PMID20575512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20575512/
RECORD: Rec_0079354 VERIFIED: YES
Provenance & Taxonomy
Psychotria leptothyrsa [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
disulfide-stabilized; exact pairings not extracted
cystine-knot scaffold
Bio-Activity Profile
Anticancer Antimicrobial
U937-GTB
26 μM
IC50
PaperIsolation, characterization, and bioactivity of cyclotides from the Micronesian plant Psychotria leptothyrsa PMID20575512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20575512/
RECORD: Rec_0133143 VERIFIED: YES
Provenance & Taxonomy
Psychotria leptothyrsa [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Cytotoxic
Lymphoma cell line
26 μM
IC50
RECORD: Rec_0166844 VERIFIED: YES
Provenance & Taxonomy
Psychotria leptothyrsa [Animal]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Anti-HIV Anticancer Cytotoxic
PaperPubMed PMID: 20575512 PMID20575512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20575512/
RECORD: Rec_0175762 VERIFIED: YES
Provenance & Taxonomy
Psychotria leptothyrsa [Plant]; Insecta [Animal]
33090; 50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID22640720 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22640720/
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