Peptide Database

Peptide NameRomiplostim

Function Ontology

Hematopoietic Thrombopoietin receptor agonist

Standard StatusStandard

Sequence Length255 amino acids

Chemical FormulaC1246H1935N339O377S9

DescriptionStandard

        MDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGGGGGIEGPTLRQWLAARAGGGGGGGG
    

Molecular Weight27984.32 Da

Isoelectric Point (pI)7.62

Net Charge (pH 7.0)1.08

Net Charge (pH 7.4) 0.34

Charge Density (pH 7.0) 0.0042

GRAVY Index-0.55

Hydrophobic Moment 0.48

Boman Index-0.02

Instability Index48.95

Aliphatic Index 68.31

Aromaticity 0.0824

Extinction Coeff. Reduced 40910.00

Extinction Coeff. Oxidized 41285.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0348114 VERIFIED: YES

Provenance & Taxonomy

OrganismEscherichia coli [Bacterium]

FamilyPeptibody

Tax ID562

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hematopoietic Thrombopoietin receptor agonist

Half-LifeImmunen thrombocytopenia patients, subQ = 3.5 d (median) (range 1-34 d)