Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length487 amino acids

Chemical FormulaC2433H3880N652O682S18

DescriptionStandard

        MREDVARGLHDVPRWASLLVLVAVGTTVTAATNPGVMVRISQKGLDYASQQGTAALQKELKRIKIPDYSGRFKIKLLGKGRYSFYSMDIREFQLPSSQISMVPNVGLKFSIGNANIKISGKWKARKRFIKTSGNFDLSVEGVSISADLKLGSNSTSGKPTVSCSSCSSHINSVHVRISKSRVGWLIRLFRKKIESTLRNKLNSQVCEKVTSSVSSKLQPYFQTLPVMTKIDAVAGINYGLVAPPTTTAETLDVQMKGEFYSQNHHNPPPFAPAVMEFPAAHDHMVYLGLSDYFFNTAGLVYQQAGVLKMTLRDDMIPKESKFRLTTKFFGTFLPEVAKMFPNMKIQIHVSASAPPHLSMQPTGLTFYPAVDVQTFAVLPNSSLASLFLIGVSTTASMEVGAKSDRLVGKLKVDRLLLELKDSNIGPFPVELLQAIMNYVVPTFVLPRVNEKLQKGFPLPTPARVQLYNTVLQPHQNFLLFGADVVHK
    

Molecular Weight53753.96 Da

Isoelectric Point (pI)9.85

Net Charge (pH 7.0)24.44

Net Charge (pH 7.4) 23.52

Charge Density (pH 7.0) 0.0502

GRAVY Index-0.04

Hydrophobic Moment 0.85

Boman Index0.08

Instability Index35.42

Aliphatic Index 91.83

Aromaticity 0.0862

Extinction Coeff. Reduced 35870.00

Extinction Coeff. Oxidized 35995.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0018000 VERIFIED: NO

Provenance & Taxonomy

OrganismPapio anubis [Animal]

FamilyBPI/LBP

Tax ID9555

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria