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MYP_069925
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Basic Information
Dermaseptin-S1 (1-29)[K4T,T12K]
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
29 amino acids
C133H226N36O35S2
Standard
Sequence
ALWTTMLKKLGKMALHAGKAALGAAADTI
Physicochemical Analysis
2953.57 Da
10.00
2.88
2.63
0.0993
0.52
0.60
0.27
5.39
108.28
0.0345
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1124.66
-8.37
40.0
41.0
100.0
206.0
3.0
28.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0251661 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
HSV-1:inhibition of virus infection in Vero cells
1.3 μM
IC50
PaperPubMed PMID: 20718719 PMID20718719 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20718719/
RECORD: Rec_0304496 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral Hemolytic
PaperPubMed PMID: 20718719 PMID20718719 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20718719/
RECORD: Rec_0315268 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral Hemolytic
human red cells
100 μM
HC50
PaperPubMed PMID: 20718719 PMID20718719 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20718719/
RECORD: Rec_0331997 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-HSV Entry inhibition
HSV-1 | Vero cells
1.3 μM
IC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperIn vitro activity of dermaseptin S1 derivatives against genital pathogens. | Savoia D, Donalisio M, Civra A, Salvadori S, Guerrini R. | APMIS. 2010 Sep 1;118(9):674-80. | DOI:10.1111/j.1600-0463.2010.02637.x | PMID:20718719 PMID20718719 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20718719/
RECORD: Rec_0336334 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Dermaseptin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Antimicrobial Antiparasitic Antiprotozoal
Human papillomavirus HPV PsV 60-70% Inhibition
5 μM
PMID20718719 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20718719/
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