Peptide Database

Peptide NameSLAY-screened peptide P2474

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length10 amino acids

Chemical FormulaC58H84N10O15

DescriptionStandard

        VLVIASSYYF
    

Molecular Weight1161.35 Da

Isoelectric Point (pI)5.49

Net Charge (pH 7.0)-0.27

Net Charge (pH 7.4) -0.48

Charge Density (pH 7.0) -0.0268

GRAVY Index1.71

Hydrophobic Moment 0.04

Boman Index0.66

Instability Index40.60

Aliphatic Index 146.00

Aromaticity 0.3000

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 406.14

LogP -0.69

H-bond Donors 15.0

H-bond Acceptors 15.0

Rotatable Bonds 33.0

Heavy Atoms 83.0

Ring Count 3.0

Amide Bonds 9.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0343426 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/