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MYP_069877
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Basic Information
SARS-CoV-S (215-232), peptide 9626
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
18 amino acids
C100H165N25O23
Standard
Sequence
TLKPIFKLPLGINITNFR
Physicochemical Analysis
2085.53 Da
11.17
2.40
2.20
0.1331
0.34
0.50
0.18
1.17
130.00
0.1111
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
781.02
-3.92
26.0
26.0
67.0
148.0
4.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0048370 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
SARS-COV:inhibition of SARS-CoV/HIV PsV virus infection in 293T/ACE2 cells
11 μM
IC50
PMID19853613 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19853613/
RECORD: Rec_0050081 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-CoV Entry inhibition
inhibition of SARS-CoV/HIV PsV virus entry in 293T/ACE2 cells
50 μM
% inhibition
Mammalian: 7.2 h; Yeast: >20 h; E. coli: >10 h
PaperIdentification of a new region of SARS-CoV S protein critical for viral entry. | Guo Y, Tisoncik J, McReynolds S, Farzan M, Prabhakar BS, Gallagher T, Rong L, Caffrey M. | J Mol Biol. 2009 Dec 11;394(4):600-5. | DOI:10.1016/j.jmb.2009.10.032 | PMID:19853613 PMID19853613 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19853613/
RECORD: Rec_0077677 VERIFIED: YES
Provenance & Taxonomy
Severe acute respiratory syndrome-related coronavirus [Virus]
Virus-derived peptide
694009;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
SARS coronavirus (Virus entry); 293T
11 μM
Luciferase assay
PaperIdentification of a new region of SARS-CoV S protein critical for viral entry. | Guo Y, Tisoncik J, McReynolds S, Farzan M, Prabhakar BS, Gallagher T, Rong L, Caffrey M. | J Mol Biol. 2009 | PMID:19853613 PMID19853613 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19853613/
RECORD: Rec_0085239 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-CoV Entry inhibition
SARS-COV | 293T/ACE2 cells
11 μM
IC50
Mammalian: 7.2 h; Yeast: >20 h; E. coli: >10 h
PaperIdentification of a new region of SARS-CoV S protein critical for viral entry. | Guo Y, Tisoncik J, McReynolds S, Farzan M, Prabhakar BS, Gallagher T, Rong L, Caffrey M. | J Mol Biol. 2009 Dec 11;394(4):600-5. | DOI:10.1016/j.jmb.2009.10.032 | PMID:19853613 PMID19853613 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19853613/
RECORD: Rec_0283088 VERIFIED: YES
Provenance & Taxonomy
Severe acute respiratory syndrome-related coronavirus [Virus]
Synthetic antiviral peptide
694009
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus
11 μM
IC50
PaperIdentification of a new region of SARS-CoV S protein critical for viral entry PMID19853613 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19853613/
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