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MYP_069872
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Basic Information
S11LD (V681 peptide derivative)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
26 amino acids
C141H233N35O33
Standard
Sequence
KWKSFLKTFKLAVKTVLHTALKAISS
Physicochemical Analysis
2946.57 Da
10.70
5.84
5.58
0.2247
0.27
0.58
0.11
2.18
108.85
0.1154
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1112.79
-6.81
41.0
40.0
101.0
209.0
5.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0226964 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli DC2
2.5 μg/mL
MIC
PaperRational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index. J Biol Chem. 2005 Apr 1;280(13):12316-29. doi: 10.1074/jbc.M413406200. PMID: 15677462. PMID15677462 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15677462/
RECORD: Rec_0227409 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Acetylation
D-Leu at 11
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa H188
10.1 μg/mL
MIC
PMID15677462 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15677462/
RECORD: Rec_0237927 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus SAP0017
32 μg/mL
MIC
PMID15677462 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15677462/
RECORD: Rec_0254834 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
The geometric mean of MIC values above six Gram-negative strains
5 μg/mL
MIC
PaperRational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index. J Biol Chem. 2005 Apr 1;280(13):12316-29. doi: 10.1074/jbc.M413406200. PMID: 15677462. PMID15677462 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15677462/
RECORD: Rec_0255394 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Acetylation
D-Leu at 11
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Salmonella typhimurium C610
3.2 μg/mL
MIC
PMID15677462 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15677462/
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