Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length541 amino acids

Chemical FormulaC2647H4253N745O749S22

DescriptionStandard

        MGMQSVAVACGALALCLALTTATNPGFVVRMTQAGLDYAQQQGMAILEKELAQLKLPDISGKSGKVRYELSRLRITSFRLPHSRITPISNVGLEVSISNSFAELNGDWRVKFLFIRDHGSFNLKVENVYMKIVLRLGSDTTGKPTISTSDCSASISKVRVRFSGKLGWLYNLFHSVIESKLRKSLERKVCDNVAKSVQNELQKQIQTLPVTARIDDKIGIDYSLVAPPRATAQSLDADLKGEFYSLAHRSTAPFSPLPLAFPPGSRAHASSYFFNTAGIAYHKAGALVFEITEAMVSGRSRTKMGKRFHLLRCSRSSQQSWRSPNKRAEGCGMGLGCQTWQHLGTGGLAMGSSVPHCPRVTVLSLQIPKKAGFSLDTSAFSAFIPQLEEMYPNMPMKFRLSTPTAPFLTIGPGGISFQPIVDAQAYAILPNSSLAPLFLLSLTGNVSAVINVRSGRIVGSLDVGRIRLSLKDSAVGHFQVELLQSLMNILTSRVVMPHLNARLDEGFPLPLLDRIQLSNILVRFHQNFLLLGADIRFQPRG
    

Molecular Weight59203.06 Da

Isoelectric Point (pI)9.95

Net Charge (pH 7.0)25.50

Net Charge (pH 7.4) 24.47

Charge Density (pH 7.0) 0.0471

GRAVY Index0.02

Hydrophobic Moment 0.71

Boman Index0.07

Instability Index39.54

Aliphatic Index 95.73

Aromaticity 0.0758

Extinction Coeff. Reduced 36900.00

Extinction Coeff. Oxidized 37400.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0195394 VERIFIED: NO

Provenance & Taxonomy

OrganismChloebia gouldiae [Bacterium]

FamilyBPI

Tax ID44316

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence