Peptide Database

Peptide NamePB1 (111-130)

Function Ontology

Antiviral

Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-Influenza A virus

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC100H167N31O35S2

DescriptionStandard

        MEVVQQTRMDKLTQGRQTYD
    

Molecular Weight2427.71 Da

Isoelectric Point (pI)5.98

Net Charge (pH 7.0)-0.49

Net Charge (pH 7.4) -0.72

Charge Density (pH 7.0) -0.0247

GRAVY Index-1.26

Hydrophobic Moment 0.27

Boman Index-0.37

Instability Index28.34

Aliphatic Index 48.50

Aromaticity 0.0500

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1131.22

LogP -13.27

H-bond Donors 39.0

H-bond Acceptors 37.0

Rotatable Bonds 85.0

Heavy Atoms 168.0

Ring Count 1.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0234982 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Other ModsContains non-standard symbols/residues: , -.

Bio-Activity Profile

Function

Antiviral Anti-Influenza A virus Replication inhibition

TargetInfluenza A virus(A/California/07/2009 (H1N1)pdm09/) | MDCK cells

Activity58±2 μM

MethodED50

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperSynthesis and antiviral activity of PB1 component of the influenza A RNA polymerase peptide fragments. | Matusevich OV, Egorov VV, Gluzdikov IA, Titov MI, Zarubaev VV, Shtro AA, Slita AV, Dukov MI, Shurygina AP, Smirnova TD, Kudryavtsev IV, Vasin AV, Kiselev OI. | Antiviral Res. 2015 Jan;113:4-10. | DOI:10.1016/j.antiviral.2014.10.015 | PMID:25446335 PMID25446335 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25446335/