Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length560 amino acids

Chemical FormulaC2862H4426N706O821S20

DescriptionStandard

        MVSIFGDYVPQSASYYFINLADEFKAPVENTSTSKAEGTEGAPWLWILPLLEMCTKMAQVQVLWGCFLLWNLYISSAQAIYPGIKARATQRALDYAVQAGMEMIEQMAKERKLPDLKGSESLEFVKIDYVNYNFTNIKINAFSFPNTSLSFVPGVGIKALTNHGTTNISTDWEVKSPLFQDTGAADLFLSGVYFTGIVVLSRNDFGHPILKLQDCYAQVSHADVSFSGELSVLYNSFAEPMEKPILKKLNEMLCPIITGEVEALNANLSMLEVLRKIDNYTLLDYSLISSPEITENYFDLNLKGVFYPLKSLRYPPFPSVPFVLPERRDSMLYIGISEYFFKSASYAYFTAGAFSFTLTTKEISNHLLHNSQAHGNMLSRIAELYILSKPFMVQVMATEPPVISLLPGNFTLDIPASIMILTQPENSTAETIVSMDFVASTNVALAILGQRLICSLSLNRFRLSLPESNRGNIEVLRFENILSSILHFGVLPLANAKLQQGFPLPNPHKISLVNSDIEVLEGFLLISTDLKYKTSKQQPGFHGWEDLHLISGQWSGKPTP
    

Molecular Weight62501.29 Da

Isoelectric Point (pI)5.41

Net Charge (pH 7.0)-11.61

Net Charge (pH 7.4) -12.55

Charge Density (pH 7.0) -0.0207

GRAVY Index0.09

Hydrophobic Moment 0.68

Boman Index0.16

Instability Index38.21

Aliphatic Index 99.09

Aromaticity 0.1107

Extinction Coeff. Reduced 71280.00

Extinction Coeff. Oxidized 71530.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0067593 VERIFIED: NO

Provenance & Taxonomy

OrganismBos indicus x Bos taurus [Animal]

FamilyBPI

Tax ID30522

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence