Peptide Database

Peptide NameSLAY-screened peptide P3751

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC81H128N22O25S

DescriptionStandard

        ACTPRSWGPGPLTPTSTI
    

Molecular Weight1842.08 Da

Isoelectric Point (pI)8.29

Net Charge (pH 7.0)0.79

Net Charge (pH 7.4) 0.58

Charge Density (pH 7.0) 0.0437

GRAVY Index-0.24

Hydrophobic Moment 0.26

Boman Index0.14

Instability Index66.43

Aliphatic Index 48.89

Aromaticity 0.0556

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 721.93

LogP -9.54

H-bond Donors 26.0

H-bond Acceptors 27.0

Rotatable Bonds 48.0

Heavy Atoms 129.0

Ring Count 6.0

Amide Bonds 17.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0057129 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/