Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length511 amino acids

Chemical FormulaC2570H4068N682O717S19

DescriptionStandard

        MSPVDSFIALWSHLKALRSWQLWRMREDVARGLHDAPRWASLLVLVAVGTTVTAAANPGVMVRISQKGLDYASQQGTAALQEELKRIKIPDYSGSFKIKLLGKGRYSFYSMDIREFQLPSSQISMVPNVGLKFSISNANIKISGKWKARKRFIKTSGNFDLSVEGVSISADLKLGSDSTSGKPTVSCSSCSSHINSVHVRISNSRVGWLIRLFRKKIESTLRNKLNSQVCEKVTSSVSSKLQPYFQTLPVMTKIDAVAGINYGLVAPPITTAETLDVQMKGEFYSQNHHNPPPFAPAVMEFPAAHDHMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFFGTFLPEVAKMFPNMKIEIHVSASAPPHLSVQPTGLTFYPAVDVQTFAVLPNSSLASLFLIGVSTTGSMEVGAKSDRLVGKLKVDRLVLELKHSNIGPFPVELLQAIMNYIVPTFVLPRVNEKLQKGFPLPTPARVQLYNMVLQPHQNFLLFGADVVYK
    

Molecular Weight56601.16 Da

Isoelectric Point (pI)9.70

Net Charge (pH 7.0)20.54

Net Charge (pH 7.4) 19.56

Charge Density (pH 7.0) 0.0402

GRAVY Index-0.00

Hydrophobic Moment 0.82

Boman Index0.09

Instability Index40.49

Aliphatic Index 93.25

Aromaticity 0.0920

Extinction Coeff. Reduced 53860.00

Extinction Coeff. Oxidized 53985.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0134689 VERIFIED: NO

Provenance & Taxonomy

OrganismMacaca nemestrina [Animal]

FamilyBPI

Tax ID9545

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence